The Life Scientific

Charles Darwin described the eye as an 'organ of extreme perfection and complication'. How this engineering marvel of nature forms out of a few cells in the developing embryo has been the big question for Veronica van Heyningen, emeritus professor at the MRC's Institute of Genetics and Molecular Medicine at the University of Edinburgh. Veronica is a world lead in the genetics of the development of the eye. She tells Jim Al Khalili about her part in the discovery of a gene called Pax-6 which turned to be a master builder gene for the eye, in all animals which have eyes - from humans to fruit flies. As she explains, further research on this gene may eventually help people with the genetic vision impairment, Aniridia. It was Veronica's research on patients with this condition which led to the gene's final discovery. She tells Jim about why it's important for scientists to engage in public discussion on the ethical implications of their work. Veronica also talks about her arrival in Britain as an 11 year old.

Alf Adams FRS, physicist at the University of Surrey, had an idea on a beach in the mid-eighties that made the modern internet, CD and DVD players, and even bar-code readers possible. You probably have half a dozen 'strained-layer quantum well lasers' in your home.

Anne Glover is currently one of the most influential scientists in Europe. She advises the President of the European Commission on the research behind issues ranging from nuclear power to genetically modified foods. She talks to Jim al-Khalili about how she makes an impact working across the many countries in Europe with different ideas about science. For example, Germany and France have very different attitudes to nuclear power. Anne Glover is also a Professor at Aberdeen University where she uses glow in the dark microbes to solve problems such as polluted land. It's a technique she developed after seeing minute glowing creatures while swimming at night in the Algarve. She tells Jim about her life in the lab, setting up a company to exploit her bioluminescent microbes and how she gets on in the world of politics.

Mark Miodownik's chronic interest in materials began in rather unhappy circumstances. He was stabbed in the back, with a razor, on his way to school. When he saw the tiny piece of steel that had caused him so much harm, he became obsessed with how it could it be so sharp and so strong. And he's been materials-mad ever since. Working at a nuclear weapons laboratory in the US, he enjoyed huge budgets and the freedom to make the most amazing materials. But he gave that up to work with artists and designers because he believes that if you ignore the sensual aspects of materials, you end up with materials that people don't want. For Mark, making is as important as reading and writing. It's an expression of who we are, like music or literature, and 'everyone should be doing it'. To this end, he wants our public libraries to be converted into public workshops, with laser cutters and 3 D printers in place of books.

Jim Al-Khalili talks to psychiatrist Vikram Patel about the global campaign he is leading to tackle mental health. He reflects on his early career working in Zimbabwe, when he doubted any western diagnoses or treatments for peoples' distress would be of much use. However, his subsequent research made him question this and come to the realisation that some conditions, like depression and psychosis, could be tackled universally. Now based in India, Vikram's research guides the public health approach he is taking. Yet critics question the application of Western categories for diagnosis and treatment to other parts of the world. Producer: Beth Eastwood.

Forensic anthropologist Professor Sue Black began her career with a Saturday job working in a butcher's shop. At the time she didn't realise that this would be the start of a lifelong fascination with anatomy. Her job has taken her to some extreme and challenging locations to identify human bodies, such as Kosovo, where she uncovered evidence used in the UN's War Crimes Tribunal in The Hague. Back home, Sue has been integral in solving many high-profile criminal cases, including cracking Scotland's biggest paedophile ring in 2009. In The Life Scientific, Jim Al-Khalili asks how she deals with the emotional pressures of the job, and why she is so fascinated by the inner workings of the human body. In her spare time, Sue Black also advises crime fiction authors like Val McDermid, providing inspiration for new plotlines and characters. In return, Val and a group of writers have offered to help with Sue's latest challenge - fundraising for a mortuary. This facility will use new techniques to embalm bodies an

Peter Higgs opens up to Jim Al-Khalili, admitting that he failed to realise the full significance of the Higgs boson and to link it to the much celebrated Standard Model of Physics. An oversight he puts down to a string of missed opportunities, including one night at physics summer camp when, most regrettably, he went to bed early. Working alone in Edinburgh in the sixties, Peter Higgs was considered 'a bit of a crank'. 'No-one wanted to work with me', he says. In 1964, he predicted the possible existence of a new kind of boson but, at the time, there was little interest in his boson. And in the years that followed, Peter Higgs says, he was 'looking in the wrong place for the application'. Three years later, the Higgs mechanism was shown to be central to the new Standard Model of Physics, which brings together three of the four fundamental forces of nature and has dominated physics ever since. Higgs met one of the key architects of the Standard Model several times, but they failed to realise they were worki

Dame Wendy Hall, Professor of Computer Science at the University of Southampton, has spent a career at the forefront of developments around the web and digital media. Trained as a mathematician, she moved to the fledgling department of computer science in the mid 1980's, a time of great change and great excitement in the field. She talks to Jim Al Khalili about the rate that things have changed, how the web is still not quite what it should be, and about the new discipline she has helped to found known as Web Science.

Australian geneticist Jenny Graves discusses her life pursuing sex genes in her country's weird but wonderful fauna, the end of men and singing to her students in lectures.

Jim Al-Khalili talks to neuroscientist and occasional stand up comedian, Professor Sophie Scott about how she is using brain imaging techniques to reveal secrets of the complexity of brain activity when we speak and when we hear others speak. And Sophie Scott explains why laughter is such an important human social tool. But why is it that if we're laughing hard it can completely override our ability to speak? Also why it's not just humans who have a funny bone: even rats laugh.

Ian Stewart, Professor of Maths at Warwick University, has had a dual career as a research mathematician and as a populariser. He wrote his first book for a general audience - on chaos theory - over thirty years. He's also the author of short stories and novels of science fiction, and of the Science of Discworld series. Ian Stewart talks to Jim al-Khalili about his life, including his research into applying mathematics to problems of biology and how he communicates the ideas of number and maths to the general public.

Life on earth has gone through a series of mass extinctions. Mike Benton talks about his fascination with ancient life on the planet and his work on the Bristol Dinosaur Project.

Professor Mark Lythgoe created and runs the largest medical imaging research facility in Europe - the Centre for Advanced Biomedical Imaging at University College London. That is quite an achievement for someone who spectacularly failed his A levels because he was dancing on the podiums of Manchester clubs or tuning the engine of his motorbike. Now the Centre does everything from testing new treatments for cancer, stroke and heart disease to probing the homing sense of pigeons. Mark Lythgoe's team develops new techniques to image the living body and its biochemical activities in ever-minute detail, with radio, light and ultrasound waves. In The Life Scientific, Mark Lythgoe talks about the frontier research at his centre and the thrill he gets from it. As well as a scientist, he is also an intrepid mountain climber and believes there are parallels between the experiences of a mountaineer and those of an inventor of new views of the human brain and body. Professor Lythgoe talks candidly about his unconven

Joanna Haigh, Professor of Atmospheric Physics at Imperial College, London, studies the influence of the sun on the earth's climate using data collected by satellites. She talks to Jim al-Khalili about how she got started on her career in climate physics: she can trace her interest in it back to her childhood when she built herself a home weather station. Jo Haigh explains why we need to know how the sun affects the climate: it's so scientists can work out what contribution to warming is the result of greenhouse gases that humans produce, and what is down to changes in the energy coming from the sun. She has sat on the Intergovernmental Panel on Climate Change and discusses with Jim how it delivers its reports. And as a prominent scientist who speaks out about the dangers of increasing man made greenhouse gases in the atmosphere, she explains how she responds to climate change deniers.

Russell Foster, Professor of Circadian Neuroscience at Oxford University, is obsessed with biological clocks. He talks to Jim al-Khalili about how light controls our wellbeing from jet lag to serious mental health problems. Professor Foster explains how moved from being a poor student at school to the scientist who discovered a new way in which animals detect light.

Jim Al-Khalili talks to the social psychologist Liz Stokoe about her research as a conversation analyst. Her interest is in the nuances of everyday chit chat but also people going on first dates, the verbal abuse between neighbours at war as well as interviews by the Police with suspected criminals. Liz is professor of social interaction at the University of Loughborough and her unusual approach involves collecting and analysing the fine details of hundreds of real, spontaneous conversations as a source of raw data. This is in contrast to more traditional means, used by other psychologists of finding out what people think by asking them directly using surveys and questionnaires. Her most recent research has overturned ideas about the best ways to teach people how to communicate, negotiate or deal with confrontation. Role play using actors to stage a scenario, has been seen by many as a gold standard training device. But, Liz says there's no evidence to show that it works. Her alternative technique is based

Is it more reckless to eat a bacon sandwich everyday or to go skydiving? What's the chance that all children in the same family have exactly the same birthday? Jim Al-Khalili talks to Professor David Spiegelhalter about risk, uncertainty and the real odds behind everyday life. As one of the world's leading statisticians, he is regularly called upon to help answer questions in high profile inquiries - like the one into the Harold Shipman murders, infant heart surgery at Bristol Royal Infirmary and the PiP breast implant scandal. Jim finds out more about the Life Scientific of the man who despite winning many awards and his research papers being some of the most cited in his field David Spiegelhalter says he isn't really that good at maths.

Ewan Birney talks to Jim Al-Khalili about his work on deciphering the human genome and the race to come up with the right number of genes that make us human. Ewan explains why he started a sweepstake to get fellow scientists to estimate the final number and why numbers were wildly wrong. He explains his role in the recent controversy over claims about the demise of 'Junk' DNA. He also talks about artificial DNA and whether it could be the future for information storage? With a colleague, he has already used a small speck of artificial DNA to store Shakespeare's sonnets. In theory, all of the world's information could be held on DNA in a space the size of a small room. If kept cold, dry and dark, DNA lasts for thousands of years so could it be the archive medium of the future?

When she started her career, physicist Dame Athene Donald took a decision that shocked her colleagues. She wanted to apply the strict rules of physics to the messy, complicated world of biology. Since then, she has taken the field of biological physics out of an unfashionable rut in the 1980s, and helped to turn into one of the most exciting and promising areas in science today. As Professor of Experimental Physics at the Cavendish Laboratory in Cambridge University, she studies the microscopic structure of everyday stuff, from plants to plastics. Jim Al-Khalili talks to Athene about her life and her passionate campaign to get more women working in science. Producer: Michelle Martin

Will we ever be able to escape the diseases of old age? That's the aim of today's guest, Prof Dame Linda Partridge who studies the genetics of ageing. From fruit flies to nematode worms, she uses simple organisms to unmask the secret processes that cause our bodies to deteriorate as we get older. But her route into science was far from normal - growing up in a Catholic convent boarding school, the girls were encouraged to be good housewives rather than diligent scientists. However, the lack of science facilities and teachers meant that the students had to run their own laboratory, ordering chemicals and tending to equipment. It was the start of a long and successful career, which has culminated in Linda becoming the Founding Director of the Max Planck Institute for Biology of Ageing in Germany and the Institute of Healthy Ageing at University College, London. Her life's goal is to produce pharmacological treatments that will help people stay healthier in old age. But what are the social and economic impac