Bbc Inside Science

For the first time the gene editing technique CRISPR has been used by injecting the CRISPR instructions into the bloodstream rather than directly into the affected organ. In a trial, six adult patients showed improvements after the treatment was used to prevent the expression of deformed proteins associated with a genetic disease. The hope is this method could treat a range of other genetic diseases, says Megan Molteni from Stat News.In the near future domestic gas boilers may be replaced by heat pumps. However, a district heating system in London is already installing the pumps in a scheme which should see 50% reductions in their carbon emissions. We visited the Citigen site to see how the plan would work, and discussed the potential for domestic heat pump roll out with Simon Evans from Carbon Brief. And why watermelons, wildflowers and pollinating insects can benefit from less attention. Evidence from Florida on how reducing methods associated with intensive farming chime with initiatives here in Britain t

The Prime Minister has announced his desire for the UK to become a 'science superpower'. A new office within the cabinet to look at science will work alongside existing science strategy and funding structures. So far it's unclear where the responsibilities between the various science policy bodies lie. James Wilsdon, Professor of Research Policy at the University of Sheffield, helps Gaia Vince pick her way through the spaghetti of overlapping organisations and Dame Ottoline Leyser, UKRI Chief Executive, gives her her take of the impact of the reorganisation.A major new trial has been announced into the effectiveness of the drug Ivermectin for the treatment of Covid-19. There's controversy surrounding the drug, which was designed to kill parasitic worms. It showed some promise against the virus in very limited lab studies. For many reluctant to vaccinate these studies seemed to suggest an alternative way to treat the virus. However, regulatory bodies disagree. It's hoped the new study and a range of other

Scientists are now looking at the question of third doses of vaccines against SARS-Cov2, and this week the Cov-Boost trial was launched. It’s being run from University of Southampton and is going to be using seven different vaccines, some at half doses, in people over the age of 30 who were early recipients of their two doses. The Chief Investigator, immunologist Professor Saul Faust explains the aims of the trial.Once we've breathed the coronavirus into our lungs, how does it spread through our bodies, despite our immune defences? Remarkably, scientists have managed to film the virus in the act of infecting lung cells and spreading between them. They then added some antibodies and watched what happened. Alex Sigal of the Africa Health Research Institute tells Gaia Vince what they saw.The UK government has pledged to plant some 2 billion trees to help get us to net zero – and that’s an awful lot of plastic casing to be littering the countryside with. A team at the Institute of Making at UCL decided to look at

Should we be vaccinating children in the UK against SARS-Cov 2? Children are rarely seriously ill if they catch Covid but infections mean missed school, and they can pass it onto older vulnerable people. The US, Canada, Israel and Dubai are some places that are already vaccinating the under 18s and Pfizer has recently published data from a trial of its mRNA vaccine in just over 2000 12-15 year olds, showing no safety concerns. Gaia Vince discusses the issue with Professor Beate Kampmann, consultant paediatrician and Director of the Vaccine Centre at the London School of Hygiene and Tropical Medicine.Dengue fever is a widespread tropical disease caused by a virus spread by the Aedes aegypti mosquito. Until now, there’s also been no way of preventing dengue aside from trying to get rid of mosquitoes, which is pretty tricky. Gaia hears from the World Mosquito Programme’s Dr Katie Anders about some positive news from a large trial in Yogyakarta in Indonesia, where mosquitoes infected with a harmless bacteria call

Sars Cov2, as the Covid19 coronavirus is called, probably began as the vast majority of new diseases do, when an animal virus infected a person – perhaps in a market or farm. There’s a large animal market in the city of Wuhan that sold wild as well as farmed animals, and studies have shown that different species of animals can infect each other with coronaviruses on their journey to market. But there’s also a possibility that the virus originated in one of two government laboratories in Wuhan. After all, we know that other viruses have escaped from labs, including the original Sars virus, which escaped multiple times from different Asian labs. Jonathan Ball, Professor of Virology at the University of Nottingham, discusses with Gaia Vince why the lab leak theory is again in the news.We know that obesity runs in families but because parents and children live in the same environment and eat the same food it is difficult to tease out how much of this relationship is inherited genetically. Researchers at Cambridge

Human impact on planet earth’s plant life might be detectable several thousand years back in fossil pollen cores taken from mud columns around the world. As Suzette Flantua and Ondrej Mottl describe in a paper published in the journal Science, a rapid acceleration in the changes in pollen species goes back further than we might have expected. This matters particularly when it comes to decisions around re-wilding and re-planting areas today in the name of conservation. As they hope to build on in future work, learning more about the state of ecosystems further back into the past might prevent us making the mistake of simply recreating different types of post-agricultural situations which might not solve the problem we are trying to fix. One of the biggest impacts on the earth’s flora today is of course influenced by our meat consumption. The BBC’s Melanie Abbott has been to see a new exhibition opening at Oxford University’s Musuem of Natural History. Produced in association with the University’s Livestock, En

Vic Gill talks to scientists who have cured a vaccine-induced blood clot patient, and meets a former top F1 chief engineer who wants to transform the fuel industry.Scientists in Vienna have been continuing to look at the rare blood clots associated with the AZ Covid-19 vaccination. Paul Knoebl describes to Vic his paper describing the diagnosis and successful treatment of a patient who developed a fever whilst skiing six days after taking it. Whilst the side effect is still condsidered incredibly rare, Paul tells Vic that a relatively simple cure - after early diagnosis - should remove any lingering hesitancy of taking a vaccine.The Science Museum reopened this week with a new exhibition looking at the science of Carbon Capture. Inside Science took former Formula One technical champ Paddy Lowe to have a look round. He is interested in Carbon Capture because he has started a new company - Zero Petroleum - that aims to do nothing less than kick start a synthetic (hydrocarbon) fuel revolution. Using carbon dioxi

Untreated wastewater "routinely released into UK rivers" is creating microplastic hotspots on riverbeds. That is the conclusion of a study in Greater Manchester, which revealed high concentrations of plastic immediately downstream of treatment works. The team behind the research concluded: untreated wastewater was the key source of river microplastic. Jamie Woodward takes Vic Gill wading in the River Tame in Greater Manchester to show some of the sites they studied, while co-author Rachel Hurley talks from Norway on the wider global questions of where microplastics get into our environment and what harm they do. The origin and location of the radioactive pollution that so devastated the lives and livelihoods of those affected by the Chernobyl disaster 35 years ago is not a mystery. But recently it has become apparent that in one small inaccessible room within the massive sarcophagus at the ill-fated power station, the nuclear fission still happening is getting slightly faster. As Neil Hyatt describes to Vic,

Despite being home to our early ancestors, attempts to find evidence of early burials in Africa have proved unsuccessful. That is until now. Professor María Martinón-Torres explains how findings from a 78,000-year-old Kenyan grave shed light on how our ancestors related to the dead. In keeping with the theme of clues from the past, Cardiff University academics have been studying the remains of crew who drowned on King Henry VIII’s favourite ship, the Mary Rose. As it turns out, Tudor England was more ethnically diverse than we previously thought. Victoria Gill speaks with University of Oxford researcher Dr Mehreen Datoo about a promising new malaria vaccine which was shown to be 77% effective in early trials. And Dr Nir Grossman, explains how his team at Imperial College London has been synchronising electrical pulses with rogue brain waves to treat tremors.

Now that NASA engineers have successfully flown a helicopter remotely on Mars planetary scientists are exploring how to use the technology elsewhere. Marnie Chesterton talks to Elizabeth "Zibi" Turtle, from Johns Hopkins University who is working on a mission to fly a drone, called Dragonfly, above Titan, one of Saturn's moons. A new report that has measured the state of over 200 000 of the world's glaciers has just been published. Bob McNabb of the University of Ulster explains why it's not good news as glaciers are melting at a faster pace than before. He says it could have a particular impact on people who live in low lying areas.At the start of April cases of the South African variant of SARS-Cov 2 were found in a number of London boroughs. In order to stop the further spread of these variants, a programme of surge testing was announced. It’s just come to an end and Marnie finds out from Public Health England’s regional director for London, Professor Kevin Fenton, how it worked.Birds aren’t very good at a

This week has seen a huge surge in Covid- 19 in India leading to concern of a "double mutant" variant, but what do we know about this B.1.617 as it is otherwise known. It was first described in October and is now in other countries including the UK. Virologist Dr Muge Cevik looks at the emerging evidence around vaccines and new variants. Climate change threatens coffee crops so it's exciting to know that researchers have found an ancient coffee variety that is drought resistant and can tolerate higher temperatures than the highly prized Arabica coffee used to make your latte - but it wasn't easy to find. In Sierra Leone Daniel Sarmu spent 4 years searching for it and Dr Aaron Davis from Kew helped to track it down using historic samples from the Herbarium at the Royal Botanic Gardens.Clothes moths do enormous damage to our jumpers and carpets, Marnie finds out how best to protect your clothes. And we hear from Mark Miodownik about the right to repair.

The story of what we understand about the rare cases of blood clots associated with certain Covid-19 vaccines is constantly evolving. In today’s programme Professor Beverley Hunt looks at the emerging evidence.How have the restrictions due to Covid 19 affected how we grieve? Professor Claire White, an expert in grief and mourning, is investigating what it means to the grief process when the traditional ways of acknowledging death are changed.Sascha Fruholz has the unenviable task of listening to people scream all day, but he has made some surprising discoveries about which types of scream people are best able to identify.

In 2016, an accelerator physics centre called Fermilab acquired a massive circular 50 foot magnet from a lab in New York. Too big for the roads, the magnet had to take a 2000km detour via New Orleans to get to its new home. This was the start of the “muon g-2” experiment. Last week, Fermilab announced some of their results, and they don’t quite add up. UK experiment lead Professor Mark Lancaster from Manchester University tells us what they have discovered about the tiny particle that is disobeying the laws that govern how our entire universe fits together.Mountain gorillas are among the most impressive and powerful primates alive today. Living in the dense forests of eastern and central Africa, they are able to communicate with other gorillas a mile away by cupping their hands and beating their chests. Primatologist Edward Wright and colleagues have been studying male silverback gorillas and explains how gorillas use chest beating to attract potential mates and suss out competitors. And Professor Corey Brad

Scientists were delighted earlier this year to find they would still have access to the EU Horizon 2020 funding and collaborations. Now, it has been revealed that membership of this group, which was previously paid for through fees to the European Union, may come directly from the science budget, at a cost of about £15 billion over the next 7 years. That’s £1-2 billion a year. Marnie Chesterton speaks with Beth Thompson, head of policy at the Wellcome Trust about the implications, and Roland Pease asks scientists working around the world how the previously announced ODA cuts are affecting their work. Native oysters help to filter coastal waters of the UK of pollutants including nitrates, while also providing habitat for other species. But their numbers have declined by 95% throughout their British range. Now, the Zoological Society of London is placing thousands of mature oysters under pontoons in marinas across the UK to let them breed, and encourage the return of the species to their former numbers. And the

The UK is reportedly halfway towards meeting its 2050 target of "net zero" carbon emissions. How did we get there and how will we achieve the next stage? ‘UK greenhouse gas emissions in 2020 were 51% below 1990 levels, according to a new Carbon Brief analysis. This means the UK is now halfway to meeting its target of “net-zero” emissions by 2050.’ Simon Evans explains his predictions from the report, outlines how we define net zero and what is required from the next few decades to ensure that the UK meets its 2050 goal. Much of Europe is attempting to replace fossil fuels, transforming transport and domestic heating to run on electrical alternatives, such as batteries and heat pumps. But where electrification isn’t possible or cost effective, such as in many homes, an alternative is still needed. Natural gas is responsible for over 30% of the UK’s total carbon emissions. Hydrogen would, theoretically, appear to be the perfect alternative, as combustion only produces water as a by product. Gaia discusses the o

We still know very little about exactly how the embryo forms out of a mass of dividing cells in those crucial first weeks after conception. This is also the time when many miscarriages occur, and scientists want to understand why. Couples going through IVF donate spare embryos for research and scientists are permitted to study them in a test tube, or in vitro, allowing them to grow and develop for up to 14 days. This 14 day rule is abided by globally, and it’s enshrined in the Human Fertilisation and Embryology Act in the UK. Thirty years ago no-one could keep these embryos alive for more than a few days but recently the techniques have moved on and they have been cultured for nearly 14 days. So should the 14 day rule be extended? Gaia Vince discusses this question with bioethicist professor Insoo Hyun of Case Western University and Harvard Medical School.There are other ways of studying this early development that don’t involve growing an actual embryo, and that’s by using just a few stem cells from it. The

On Friday 5th March China published a draft for its 14th five-year plan in Beijing. The document acts as a national economic blueprint and was expected to provide an outline as to how the world’s biggest emitter of greenhouse gas emissions planned on tackling its target of reaching net zero emissions by 2060, put forward by President Xi Jinping last September. It appears that greenhouse emissions could continue to increase by 1% or more each year up until 2021. Sam Geal, acting CEO at China dialogue, explains how influential Chinese efforts are when combatting climate change. Since the late 1980s conservationists have used captive breeding to prevent the extinction of North America’s only native ferret species, the black footed ferret (Mustela nigripes). Now, an individual called WIlla, who died without leaving any offspring over 30 years ago has been cloned. Her genes represent 300% of the current genetic diversity of the species, and could help boost the chances of these animals. Dr Bridget Baumgartner wor

With global warming continuing to increase at an alarming rate, we need all the help we can get to lock up the carbon that we’ve released into the atmosphere. Fortunately, plants have evolved to do just this, but there’s a whole class of plants that often get forgotten: the mangroves and seagrasses that grow between land and sea, which are among the planet’s most effective carbon sinks. Gaia Vince talks to Fanny Douvere, head of the marine programme at UNESCO, about its new report that shows the importance of blue carbon locked up in its marine World Heritage Sites. And Professor Hilary Kennedy, of Bangor University, explains why seagrasses are so effective at locking up carbon. Roland Pease reports on the secret journey made by one of the most valuable of human fossils, Little Foot, from Johannesburg to Oxfordshire, where it was scanned at the Diamond Light Source facility – one of the most powerful X-ray machines in the world. He talks to some of the main players about the hush hush voyage, and what they’re

On Thursday, The UN Environmental Programme published a report called Making Peace With Nature. It attempts to synthesise vast amounts of scientific knowledge and communicate “how climate change, biodiversity loss and pollution can be tackled jointly within the framework of the Sustainable Development Goals”. But it also offers clear and digestible messages that governments, institutions, businesses and individuals can act upon. Concluding BBC Inside Science’s month-long look at some of the challenges ahead of COP26 in Glasgow later this year, and its sister biodiversity meeting in China, Vic speaks with the report’s co-lead Prof Sir Robert Watson FRS and the Tyndall Centre’s Prof Rachel Warren, also a contributing author. Can all the ills of the natural world really be tackled at once?Game-shooting, for sport and food, has traditionally used the toxic metal lead for ammunition. In other parts of the world its use has been banned for the dangers to the human food chain and to the pollution in natural environ

On Thursday 18th Feb 2020 Nasa’s Perseverance Rover is due to touch down – gently and accurately – in the Jezero crater on Mars. Using similar nail-biting Sky Crane technology as its predecessor Curiosity, if successful it will amongst many other things attempt to fly the first helicopter in the thin Martian atmosphere, and leave small parcels of interesting samples for future missions to collect and return to earth. Unlike previous Martian landings of course, there are no mass-landing parties to be held because of Covid. So Vic Gill invites you to join her and current Curiosity and future Rosalind Franklin (ESA’s 2023 Rover) team scientists in nervously awaiting the signal of success.Dr Susanne Schwenzer was so tense during Curiosity’s final approach in 2012 that she managed to draw blood from her own hand from clutching her mobile phone too hard. BBC Inside Science expects nothing less this time round. Dr Peter Fawdon has been part of the team seand examining the landing site for ESA’s Martian lander and Ro