Acs Research - Theorylab

Lipids! Their role in glioblastoma and potential as a therapeutic target

Informações:

Sinopsis

Lipids are fat molecules normally found in the membranes that surround each cell in the body. They also play a critical role in cellular communication. Ray Blind, PhD, and his lab have been investigating how a particular lipid turns cancer genes on and off in glioblastoma. In this interview he talks about how this happens as well as the very exciting therapeutic potential of his work. Ray Blind, PhD, is Assistant Professor of Medicine at Vanderbilt University Medical Center. 2:57 – Lipids? What are lipids? Why are they important? 9:40 – What does the cutting edge of science tell us what it’s like in the nucleus? 15:28 – A nuclear lipid the Blind Lab studies interacts with chromatin. Why is that interaction important? 18:24 – How this nuclear lipid might be especially important in glioblastoma 21:39 – “You know the lipid is there, you know it has a role in cancer, we also assume that it has a role in normal cell development—is there a way to block it and not impact normal development or function? What