Acs Research - Theorylab

It’s difficult to comprehend how busy and densely packed it is on the inside of a cell. But understanding cell structure and organization is critical to developing new cancer drugs. Isaac Klein, MD, PhD, a postdoctoral fellow in the Richard Young Laboratory at the Whitehead Institute, recently published findings that could have wide-ranging implications for the understanding of how cancer drugs work. Dr. Klein joined the podcast to explain why knowing how to get cancer drugs to exactly the right place in a cell—at a sufficient concentration—is critical to developing new and more effective cancer treatments. Isaac Klein, MD, PhD, is the American Cancer Society Layla Rohani Postdoctoral Fellow. His grant was specially funded by the Rohani Family and Friends. He is a physician and scientist at the Dana-Farber Cancer Center and Whitehead Institute at MIT. 4:11 – What is it like inside of a cell? Is organization a challenge for cells? 8:30 – A great analogy to help us understand cell organization and “con