Acs Research - Theorylab

What is it that goes so wrong when cancer cells develop the ability to divide indefinitely? Dr. Johannes Walter joined the TheoryLab podcast to help answer that question. He and his lab are at the leading edge of discovery science aimed at understanding DNA replication and repair, areas that are critical to understanding cancer and developing new therapies. Johannes Walter, PhD, is an American Cancer Society Research Professor, Professor of Biological Chemistry at Harvard Medical School, and Member of the Howard Hughes Medical Institute. Research Professor. He’s also the co-founder of MOMA Therapeutics, which aims to “discover the next generation of precision medicines by targeting the molecular machines that underlie human disease.” 3:04 – What is DNA? Why is it so important to cell division? 7:39 – What causes DNA damage? 11:34 – How damaged DNA is most often repaired 14:36 – When DNA repair goes wrong 17:43 – Using frog egg extract to study DNA repair and understand cancer in humans 21:44 – Why f