Acs Research - Theorylab

New findings in cancer research: Structure of Med-PIC, the fine control of gene expression, and more

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Sinopsis

In this episode—which is for a scientific audience until the 27-minute mark—a current American Cancer Society grantee and a former grantee spoke with each other about their recently published new findings in cancer research. Alessandro Gardini, PhD, an Assistant Professor at The Wistar Institute, studies the epigenetic control of transcription during cell differentiation and oncogenesis. He recently published work in Cell titled “The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer:” https://pubmed.ncbi.nlm.nih.gov/34004147/. Yuan He, PhD, is Assistant Professor (but just received word that he’s being promoted to Associate Professor!!) at Northwestern University. The He lab The He lab uses cryo-electron microscopy (cryo-EM) and other biophysical and biochemical approaches to understand “the molecular mechanisms by which large, multi-subunit complexes engage in DNA-centric processes.” Dr. He recently published findings in Science on, “Structure of the human M