Collège De France (général)

Hugues de ThéCollège de FranceOncologie cellulaire et moléculaireAnnée 2023-2024Exploring the World of Protein Post-translational ModificationsConférence - Tony Hunter : Noncanonical Protein Phosphorylation – Is Histidine Phosphorylation Used as a Reversible Regulatory Mechanism?Tony HunterSalk Institute, La Jolla, California, USARésuméProtein phosphorylation is not restricted to serine, threonine and tyrosine, but can occur on six other amino acids, including histidine. In this lecture, I will discuss what is known about non-canonical protein phosphorylation, focusing on our recent work developing new tools to study histidine phosphorylation in cells and tissues, and their use to investigate the possible roles of histidine phosphorylation in liver cancer, pediatric neuroblastoma, breast cancer and pancreatic cancer.Histidine phosphorylation of proteins was discovered in 1962, before tyrosine phosphorylation, but much less is known about this PTM because phosphohistidine is chemically very labile and therefor