Authentic Biochemistry

Cellular long chain acyl-CoA concentrations are controlled by multiple networked and coherent  metabolic pathways ( including mitochondrial β-oxidation versus Golgi-ER-PL complex lipid synthesis versus glyceropholipid and sphingolipid hydrolysis), which functionally associate  resident  acyl-CoA in cellular bioenergetic and signaling pathways. Thus, the regulation of PFK-1 by its direct interaction with acyl-CoA generates downstream interconnected alterations in metabolic flux through glycolysis, the OPP and mitochondrially associated oxidative metabolism plus  vesicular trafficking and directed  subcellular localization  associated with porosomes. Biol Open. 2019 Oct 15; 8(10): bio040311. Biochem Soc Trans. 2015 Apr;43(2):193-8.) J of Molecular and  Cellular Medicine 2014. 18: pp.1927 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message