Authentic Biochemistry

If  γ-aminobutyric acid (GABA) concentration drops significantly in the synaptic cleft, excitotoxicity can obtain, sometimes presenting with epileptic convulsions.This can be reversed by decreasing the concentration of L-glutamate via control over the activity of glutamate dehydrogenase, glutamine synthetase and glutamate transporters or by  the inhibition of  γ-aminobutyric acid aminotransferase (GABA-AT), which catalyzes the conversion of GABA to the excitatory neurotransmitter l-glutamic acid. Trends in Cell Biology 2020. 30.6: 440-451. Chem. Rev. 2018. 118. 7: 4037–4070 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message