Discovery

Humanity’s impact on the Earth is so profound that we’re creating a new geological time period. Geologists have named the age we’re making the Anthropocene. The changes we’re making to the atmosphere, oceans, landscape and living things will leap out of the rocks forming today to Earth scientists of the far future, as clearly as the giant meteorite that ended the Age of the Dinosaurs does to today’s researchers. In this four part series, journalist Gaia Vince looks at the impact of these planetary transformations from the perspective of geological time. When was the last time comparable events happened in Earth history, and are what are the key marks we’re making on the planet that define the Anthropocene?In this first programme, Gaia hears how the hand of humanity on the surface of the continent is geological in its sheer scale and its imprint will remain for millions of years. Through mining and quarrying, we shift billions more tonnes rock and sediment annually than all of the planet’s great rivers a

We are in desperate need of new medicines for the major diseases facing us in the 21st century such as Alzheimer's and obesity. And we are running out of antibiotics that are effective against bacteria that are now resistant to many old varieties. As bringing new and improved drugs to patients becomes more difficult and more expensive - it can take 20 years and around $1 billion to bring a medicine to market. In the second programme looking at the problem with drug discovery, Geoff Watts asks what can be done to get new pharmaceutical treatments to patients.He discovers that the industry is risk averse and regulations to ensure that drugs are safe and effective are burdensome. But there are pilot projects to speed up the process. Geoff finds out that the experts believe that there needs to be a fundamental change in the drug development process, and the key ingredient is collaboration - between industry and academia and between different drug companies. He also discovers that the medical charity, the Wellco

We are in desperate need of new medicines for the major diseases facing us in the 21st Century such as Alzheimer's and obesity. And we are running out of antibiotics that are effective against bacteria that are now resistant to many old varieties. As bringing new and improved drugs to patients becomes more difficult and more expensive - it can take 20 years and around $1 billion to bring a medicine to market - Geoff Watts asks what's gone wrong and what can be done to get new pharmaceutical treatments to patients.Geoff talks to a number of researchers who have worked both within the pharmaceutical industry and publicly funded laboratories to get their views on why the source of drugs has dried up. These include Dr Patrick Vallance, of global pharmaceutical giant GSK, Professor Paul Workman of the Institute of Cancer Research, and Professor Chas Bountra of Oxford University's Structural Genomics Consortium. They argue that the age of the blockbuster drug which can treat millions of patients is over and that we

Nine million people in the UK alone have significant hearing problems. The mechanisms in our ears that help us hear are incredibly sensitive and are easily damanged by environmental hazards such as loud noises and chemicals or simply the passage of time. Despite the fact that many of us will gradually lose our ability to hear as we as a society grow older, many of us don’t actually know that much about the causes and consequences of deafness. What does the world sound like to a deaf person? How do the brain and ears work together to make sense of sound? And how far have scientists come in helping to restore impaired hearing? In this edition of Discovery, Dr Carinne Piekema speaks with Harry Thomas who has been deaf since birth along with experts in the field of auditory neuroscience to find out about what it is like living with hearing loss on a personal and scientific level. By recreating everyday sounds as if heard by someone like Harry wearing a hearing aid or with a cochlear implant, she will also try to

Is our taste in music, and how it's changed over the centuries, governed by creative genius or simply by survival of the fittest sounds, chosen by us the consumer? Does Darwin's theory of natural selection apply to more than just life on the planet? The idea of survival of the fittest and cultural evolution can be applied to many aspects of our lives; from fashion to the naming of our children. In a world of digital sampling scientists have designed an experiment to see if they can create the perfect song by asking individuals to choose which tunes survive and reproduce to create new tunes and which ones die out. If they can do this, where does that leave today's musical producers and composers? Do we still need a trained mind to compose truly amazing music?Producer: Ania Lichtarowicz

What can astronomy tells us about great literature? Forensic astronomer Don Olson tells Andrew Luck-Baker about two of his investigative cases. He explains how plotting the path of the moon in 1816 solved a controversy about Mary Shelley's novel Frankenstein. The Texas State University professor also outlines his theory that a star referred to in Shakespeare’s Hamlet was inspired by a spectacular supernova which blazed in sky one year during the playwright’s childhood.(Image: Baron Frankenstein, played by Peter Cushing, leans over his monstor in the film The Curse of Frankenstein. Credit: Getty Images)

One hundred years ago, the first humans reached the South Pole of this planet. More than 40 years ago, man first walked on the moon. When will our species first set foot to explore the planet Mars? Kevin Fong seeks a likely launch date. He asks who will get us there and why we really need to explore the Red Planet.(Image: An image, released by NASA, of the terrain of Mars taken by the Curiosity rover. Credit: AP Photo / NASA / JPL-Caltech / MSSS)

Jim Al-Khalili finds out about the life scientific of the British Antarctic Survey biologist Lloyd Peck. Amongst other creatures he studies giant sea spiders. They and other small animals grow far bigger than usual in the extreme cold. Diving is an important part of Lloyd's job and Jim hears what it's like to play football under the ice. Studies suggest that the sea temperature is rising, and Lloyd investigates whether the animals he researches will be able to adapt and survive. And Lloyd talks about the difficulty of leaving his family behind in the UK while he spends months in the Antarctic.Producer: Geraldine Fitzgerald(Image: A young woman studying a sea spider in the Science Museum in London. Credit: AFP / Getty Images)

One hundred years ago, Scott reached the South Pole.Fifty years later, the first geologist briefly walked on the moon. Kevin Fong asks if why we might want to return to the lunar surface and what will get us. He talks to that first lunar geologist of Apollo 17, Harrison Schmitt and Nasa's Chief Administrator Charles Bolden, among others.

Jim Al-Khalili meets Cambridge University neuroscientist Barbara Sahakian. She talks about her Life Scientific finding drugs to slow down the memory losses that happen in Alzheimer's disease. She worked in some of the first memory clinics that were set up in the US and the UK to help people who had problems remembering and has developed tests to find out if peoples' forgetfulness is the first sign of dementia. More recently she has turned her attention to drugs that can improve the performance of surgeons or pilots or other professions where it is important to be alert for long times. Barbara says that they could even be used to make us more entrepreneurial. And some students are taking them as they think they could be giving them an edge in exams. Jim and Barbara discuss the thorny ethical issues raised by these uses of these drugs.

Kevin Fong looks beyond the failure of Robert Falcon Scott's expedition to be the first to reach the South Pole and focuses instead on the scientific legacy of Scott's explorations of Antarctica between 1901 and 1912.In recent years, much has been written about Scott the polar loser and bungler. But that personalised focus ignores the pioneering scientific research and discoveries. The revelations transformed Antarctica from an unknown quantity on the map into a profoundly important continent in the Earth's past and present. Before Scott and Shackleton trekked across the vast ice sheets in the early 1900s, no-one was sure whether there was even a continent there. Some geographers had suggested Antarctica was merely a vast raft of ice anchored to a scattering of islands. The science teams on Scott’s expeditions made fundamental discoveries about Antarctic weather and began to realise the frozen continent's fundamental role in global climate and ocean circulation. They discovered rocks and fossils which showed

Discovery this week goes in search of the Gangetic River Dolphin, an extraordinary creature which inhabits the muddy waters of the Ganges and Brahmaputra rivers. Not long ago, the dolphin was a common sight for people along these mighty water ways, but now it's one of the world's rarest freshwater mammals. Andrew Luck-Baker joins Indian biologists studying the dolphins and the threats to them along the stretch of the Brahmaputra in the state of Assam. In a joint project between Aaranyak, an Indian conservation organisation, and the Zoological Society of London, the scientists are also mobilising local communities to protect this special animal and the ecosystem they share with it.

After the most daring and complex landing of a robot on another planet, the search for evidence of life on Mars enters a new era. Nasa's Curiosity rover is now sitting inside Gale Crater, a vast depression close to the Martian equator. Also known as the Mars Science Laboratory, the one tonne machine is the most sophisticated science robot ever placed on another world. Over the coming years Curiosity will climb a mountain at the crater's heart, gathering evidence on one of science's greatest questions – was there ever life on Mars? The $2.5 billion project will discover whether Mars once had conditions suitable for the evolution and survival of life. BBC Space specialist Jonathan Amos talks to mission scientists about where Curiosity is going and what it will do as it trundles up Mars' Mount Sharp.(Image: Nasa's Curiosity rover. Credit: Nasa/JPL-Caltech/PA Wire)

Gareth Mitchell meets the engineers who are designing flying cars and green aircraft. Gareth has a go at flying a personal aircraft in the flight simulator at Liverpool University. Doctors Mike Jump and Mark White explain that the EU-funded project MyCopter is seriously looking at the prospect of flying personal vehicles that are as easy to drive as a car. Sophie Robinson, a Ph.D student at Liverpool University, explains how her research into the safety and stability of auto-gyros, flying machines that already exist for personal travel, could set standards for the flying cars of the future.Prof Jeff Jupp, who worked on the wings of the largest passenger plane, the A380, talks about alternative fuels to kerosene and new designs for engines. These look rather old-school, as they have propellers, but they will make the aircraft more energy efficient. But there may be a downside in that they could be noisier and slower than jet engines. Dr Will Graham describes the work he has done on the Silent Aircraft project

Gareth Mitchell meets the engineers who will transform the way we fly around the world and finds out what aircraft might look like in the future. Gareth visits the flight gallery at the Science Museum in London with the curator, Dr Andrew Nahum, who shows him how the basic shape of aircraft has hardly changed in 70 years, since the days of the DC3. Andrew Nahum also talks about why Concorde was in service for such a short time. David Caughey, Emeritus Professor of Aeronautical Engineering at Cornell University, points out that the blended wing shaped aircraft is more energy efficient. So Gareth asks why we don't see them in service today - the answer is that apart from the innate caution of the airline manufacturers, the passengers would have no windows and it could be hard to evacuate such a craft speedily in an emergency. Gareth talks to Professor Jeff Jupp who worked on the wings of the largest passenger plane, the A380, about the technical challenges. Professor Paul Weaver at Bristol University tells Ga

Chemist Andrea Sella explores the current race to do photosynthesis better than nature ever achieved. In just a few hundred years mankind has burnt fossil fuels that had taken natural photosynthesis billions of years to create.Now, around the world hundreds of millions of pounds are being spent on the race to develop a robust, cheap and efficient way to turn the light from the sun into fuels we can use. At a time when politicians everywhere debate the economic and climatic burdens of our future energy needs, such a "solar fuel" would be a genuinely novel alternative energy.(Image: Some beech leaves. Credit: Martin Dohrn /Science Photo Library)

Could creating "blood" in the laboratory make infections passed on through blood transfusions a thing of the past? Vivienne Parry investigates.The drive behind the quest for creating a blood substitute was originally from the US Military - during the Vietnam War a clean, reliable and portable alternative to donor blood would have helped to save many lives. Donated blood can only be kept for a limited time, needs refrigerating and has to be cross matched according to which ABO group people belong to. The "universal donor" - O negative blood - can be used on accident victims before a match is found. But it's in very short supply and often many units of blood are required.The history of creating blood has had a chequered past - with some products abandoned because of side effects and others proving too costly to produce. One analysis of clinical trials on blood substitutes in 2008 revealed a higher incidence of heart attacks in patients who'd been given them, compared with those who received human blood.Some sci

Gene therapy - repairing malfunctioning cells by mending their DNA - offers an elegant solution to diseases, such as cystic fibrosis, caused by a single flawed gene. It's a very simple concept to describe - simply insert a 'normal' gene to do the job - but it's this process, the delivery of the gene, that's proving to be so difficult and time consuming. Since the first human study began in 1990 the field has struggled with various technical challenges and set-backs.But over a decade on, researchers are beginning to report successes in treating several devastating diseases. Geoff Watts finds out about some of the new techniques for gene therapy, and discovers how these are now being used in a trial of a new method of gene therapy for cystic fibrosis. Twelve years ago, a group of scientists from Imperial College in London, Oxford and Edinburgh formed the Cystic Fibrosis Gene Therapy Consortium. This year they started the world's biggest trial of gene therapy for cystic fibrosis.Funded by the Cystic Fibrosis Tru

Alan Turing, born 23 June 1912, is famous for his key role in breaking German codes in World War II. But for mathematicians, his greatest work was on the invention of the computer. Alan Turing's brilliance at maths was spectacular. Aged 22, just a year after his graduation, he was elected a fellow of King's College Cambridge. And it was just a year after that, that he turned his attention to problems in the foundations of mathematics and ended up showing that a simple machine, set up to read and write numbers and to run a few basic functions, could in principle do all the things that are do-able in mathematics. His 'universal' machine was just a concept - a paper tape that could be read, interpreted and acted on robotically. But the concept was profound. World War II shortly afterwards took Turing's talents into other directions, but even while designing machines at Bletchley Park to break the German Enigma codes, he was wondering how much more a computing machine might do - play chess for example.And althoug

Alan Turing - born a hundred years ago on June 23 - is most famous for his key role in breaking German codes in World War II. But for mathematicians, his greatest work was on the invention of the computer. Discovery explores the legacy of the great man with a two-part special.Alan Turing's brilliance at maths was spectacular. Aged 22, just a year after his graduation, he was elected a fellow of King's College Cambridge. And it was just a year after that, that he turned his attention to problems in the foundations of mathematics and ended up showing that a simple machine, set up to read and write numbers and to run a few basic functions, could in principle do all the things that are doable in mathematics. His 'universal' machine was just a concept - a paper tape that could be read, interpreted and acted on robotically. But the concept was profound. World War II shortly afterwards took Turing's talents into other directions, but even while designing machines at Bletchley Park to break the German Enigma codes, h