Neurology® Podcast

In the first segment, Dr. Jason Crowell talks with Dr. Brian Callaghan about rising out-of-pocket costs for commonly prescribed neurologic medications. In the second part of the podcast, Dr. Jeffrey Ratliff focuses his interview with Dr. Stefan Pulst on ataxias.  CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

In the first segment, Dr. Stacey Clardy talks with Dr. Annie Lannuzel about the importance of biological diagnosis in long-term outcome in neuroZika. In the second part of the podcast, Dr. Will Rondeau focuses his interview with Dr. Stuart Connolly on his NEJM paper on the full study report of andexanet alfa for bleeding associated with factor Xa inhibitors. The paper can be found here: https://www.nejm.org/doi/full/10.1056/NEJMoa1814051. CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

This month’s Delayed Recall highlights episodes on developments and scandals related to genetic testing and technology in neurology. Dr. Jason Crowell and Dr. Josephine Johnston of the Hastings Center start the show discussing the ethical and philosophical implications of gene editing., which first aired on December 18th, 2018. The next segment, also from December 18th, has Dr. Stacey Clardy and Dr. Stefan Pulst focusing on the scientific and societal impact of the recent first reported gene editing using the CRISPR technology. Following this segment is one from December 3rd and finds Dr. Jeff Waugh talking with Dr. Saadet Andrews about her paper on the genetic landscape of pediatric movement disorders and management implications. This episode continues with an interview on a Neurology: Genetics on the long journey to diagnosis for patients with mitochondrial disease between Dr. Jason Crowell and Drs. John L.P. Thompson and Michio Hirano from April 3rd, 2018. The episode wraps up with a talk between Dr. Jeffr

In the first segment, Dr. Lindsay Higdon talks with Dr. Ivan Sanchez Fernandez about his paper on the meta-analysis and cost-effectiveness of second-line antiepileptic drugs for status epilepticus. In the second part of the podcast, Dr. Stacey Clardy talks with Dr. Anthony Fauci about the measles outbreak of 2019. You can read the paper in NEJM: https://www.nejm.org/doi/full/10.1056/NEJMp1905099. 

In the first segment, Dr. Jeffrey Ratliff talks with Dr. Tamara Milka Pringsheim about her practice guideline recommendations summary paper on the treatment of tics in people with Tourette syndrome and chronic tic disorders. In the What's Trending segment, you'll hear the second part of an interview between Dr. Jason Crowell and New York Times staff writer Pam Belluck on CRISPR and gene editing.

In the first segment, Dr. Stacey Clardy talks with Dr. Jenny Linnoila about her March 2019 Neurology: Neuroimmunology & Neuroinflammation paper on a mouse model of anti-NMDA receptor post–herpes simplex encephalitis. In the second segment, Jason Crowell talks with Pam Belluck of the New York Times about He Jiankui, gene editing, and CRISPR. 

In the first segment, Dr. Gregory Day talks with Dr. Brigid Waldron-Perrine about her Neurology: Clinical Practice paper addressing the Montreal Cognitive Assessment as a screening tool. In the second part of the podcast, Dr. Jeffrey Burns focuses his interview with Dr. Mathias Jucker on how serum neurofilament dynamics predict neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease. The article can be found in Nature: https://www.nature.com/articles/s41591-018-0304-3.

In the first segment, Dr. Stacey Clardy talks with Dr. Mathias Buron about his paper addressing the comparative effectiveness of teriflunomide and dimethyl fumarate. In the second part of the podcast, Dr. Jason Crowell focuses his interview with Dr. Joanna Hellmuth on the rise of pseudomedicine for dementia and brain health.

In the first segment, Dr. Stacey Clardy talks with Dr. Caterina Lapucci about her paper addressing how much periventricular lesions assist in distinguishing migraine with aura from CIS. In the second part of the podcast, Dr. Jason Crowell focuses his interview with Sarah Karlin-Smith and Sarah Owermohle from Politico on drug pricing.

In the first segment, Dr. Derek Bauer talks with Dr. Stephan Schuele about his paper on automated seizure detection accuracy for ambulatory EEG recordings. In the second part of the podcast, Dr. Nicole Chiota-McCollum focuses her interview with Dr. Kevin Barrett on the SHINE stroke trial.

Dr. Luca Bartolini discusses autoimmune encephalitis and the role of antibody testing based on a Practice Current survey run between November 2017 and May 2018.

Dr. Jeffrey Ratliff talks with Dr. Anneleen Berende about her paper on the effect of prolonged antibiotic treatment on cognitive performance in patients with Lyme borreliosis. Dr. Andrew Southerland focuses his interview with Dr. Stephen Klasko on hospitals of the future, following a panel at the World Economic Forum in Davos, Switzerland. The article can be found here: https://www.statnews.com/2019/01/26/dispatch-from-davos-future-hospitals/.

This month’s Delayed Recall highlights episodes on autoimmune neurology. A segment from October 23, 2018 finds Dr. Stacey Clardy talking to Dr. Andrew McKeon about his paper on paraneoplastic neuronal intermediate filament autoimmunity. This episode concludes with an interview on a Neurology: Neuroimmunology & Neuroinflammation paper on IgLON5 autoimmunity between Dr. Stacey Clardy and Dr. Andrew McKeon from March 27, 2018.

In the first segment, Dr. James Grogan talks with Dr. David Llewellyn about his Neurology: Clinical Practice paper on predictors of dementia misclassification when using brief cognitive assessments. In the second part of the podcast, Dr. Jason Crowell focuses his interview with Dr. Rob M.A. de Bie on a randomized delayed-start trial of Levodopa in Parkinson’s Disease, published in the New England Journal of Medicine. The article can be found here: https://www.nejm.org/doi/full/10.1056/NEJMoa1809983.

1. A multicentre comparison of MOG-IgG cell based assays. 2. [What’s Trending]: the DEFUSE 3 study. In the first segment, Dr. Stacey Clardy talks with Dr. Paddy Waters about his paper on a multicentre comparison of MOG-IgG cell based assays. In the second part of the podcast, Dr. Andrew Southerland focuses his interview with Dr. Adam de Havenon on the DEFUSE 3 study.  CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. The prevalence of MS in the United States: A population-based estimate using health claims data. 2. [What’s Trending]: Neurology on the Hill and advocacy issue. In the first segment, Dr. Stacey Clardy talks with Dr. Mitch Wallin about his paper examining a population-based estimate on the prevalence of MS in the United States. In the second part of the podcast, Dr. Jason Crowell focuses his interview with Dr. Nick Johnson on Neurology on the Hill and advocacy issues. CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Quality Improvement in Neurology: Universal Neurology Quality Measurement Set Executive Summary2. [What’s Trending]: The 2018 report of the Lancet Countdown on health and climate change: shaping the health of nations for centuries to come. In the first segment, Dr. Stacey Clardy talks with Dr. Wayne Anderson and Dr. Justin Martello about their paper on quality improvement in neurology. In the second part of the podcast, Dr. Jason Crowell focuses his interview with Dr. Nick Watts on health and climate change shaping the health of nations for centuries to come. DISCLOSURES: Dr. Stacey Clardy has received research support from Western Institute for Biomedical Research (WIBR). Dr. Wayne Anderson reports no disclosures. Dr. Justin Martello has received travel funding or speaker honoraria from 1) Teva, cash, (2) Abbvie, cash, (3) Lundbeck, cash and is a member of the AAN’s Quality and Safety Subcommittee. CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by ans

1.Physical activity, common brain pathologies, and cognition in community-dwelling older adults 2. [What’s Trending]: Deep space medicine. In the first segment, Dr. Jeff Burns talks with Dr. Aron Buchman about his paper on physical activity, common brain pathologies, and cognition in community-dwelling older adults. In the second part of the podcast, Dr. Jason Crowell focuses his interview with Dr. Alejandro Rabinstein on the medicine of deep space. Dr. Jeff Burns has served on the DSMB for three NIH-funded trials; has received honorarium and travel for speaking at an Astra-Zeneca symposium; has served on the editorial board of Journal of Alzheimer's Disease; has served as a consultant for protocol development for Stage 2 Innovations; has received commercial research support from Lilly, Avid Radiopharmaceuticals, Toyama Chemical Company, Merck, Biogen, AbbVie, vTv Therapeutics, Janssen, and Roche and for investigator-initiated studies from Eli Lilly and Astra-Zeneca; has received governmental research support

1.Quality of Life Outcomes in Patients Presenting for Evaluation of Central Nervous System Tumors 2. [What’s Trending]: 'Landmark study’ shows brain cells revamp their DNA, perhaps sparking Alzheimer’s disease. In the first segment, Dr. Ted Burns talks with Dr. Irene Katzan about her paper on quality of life outcomes in patients presenting for evaluation of central nervous system tumors. In the second part of the podcast, Dr. Jeff Burns focuses his interview with Dr. Jerold Chun on a 'Landmark study’ showing brain cells revamp their DNA, perhaps sparking Alzheimer’s disease.Dr. Ted Burns has served on scientific advisory boards for Argenx, Momenta, received travel funding or speaker honoraria from Argenx, Alexion and received support for consulting activities from UCB Pharma, CSL Behring, Momenta, Argenx. Dr. Irene Katzan has served on editorial boards for Stroke (American Stroke Association), 2014-present Editorial Board - Circulation: Cardiovascular Quality & Outcomes (American Heart Association) 2013 –

1. Reducing neurodisparity: Recommendations of the 2017 AAN Diversity Leadership Program 2. [What’s Trending]: Mapping Symptoms to Brain Networks with the Human Connectome. In the first segment, Dr. Teshamae Monteith talks with Dr. Roy Hamilton about his paper on reducing neurodisparity. In the second part of the podcast, Dr. Stacey Clardy focuses her interview with Dr. Michael D. Fox on mapping symptoms to brain networks with the human connectome.DISCLOSURES Dr. Teshamae Monteith has served on Scientific Advisory Boards for Lilly, Supernus, Teva, Electrocore, Promius and is an editorial advisory board member for Neurology. Dr. Roy Hamilton has served without compensation on the scientific advisory board for an NIH-funded R21 project titled ""Combining tDCS and neurorehabilitation to treat age-related deficits of mobility and cognition (UPfront Walking Study) as the data safety monitor. Dr. Hamilton has served on editorial boards for (1)Cognitive and Behavioral Neurology, editorial board member, and (2)Restor